Micro RNAs In Periodontal Disease – A Review
DOI:
https://doi.org/10.22452/adum.vol27no3Keywords:
microRNA, biogenesis, profiling, innate immunity, acquired immunity, bone remodellingAbstract
microRNAs (miRNAs) constitute a family of small, non-coding RNA molecules that regulate gene expression and protein expression. microRNAs have influence on a broad range of physiologic and pathologic conditions. They are also considered as promising biomarkers especially when they are secreted extracellularly. In the inflammatory pathways, they dysregulate the molecular processes and contribute to the development of chronic inflammatory diseases including periodontitis. In this review, we provide an overview of miRNA characteristics, biogenesis, mechanisms of action and profiling methods. In addition, the role of miRNAs in the pathobiology of periodontitis, especially those pertaining to the cellular and molecular pathways of inflammation has been considered to enhance our understanding of the pathobiology of periodontitis.
Downloads
Published
Issue
Section
License
- The Faculty of Dentistry, Universiti Malaya holds the copyright of the published manuscript including all its components such as supplementary information, graphical contents and raw data without any restrictions.
- The author grant the Faculty of Dentistry, University of Malaya assignable and sub-licensable right, unlimited in time and territory, to copy-edit, reproduce, publish, distribute, transmit, make available and store the Article, including abstracts thereof, in all forms of media of expression now known or developed in the future, including pre- and reprints, translations, photographic reproductions and extensions.
- After acceptance for publication in Ann Dent UM, the author(s) have the right to use any of its components in whole or in part for academic purposes such as, presentation in scientific conferences and seminars.
